Alcohol use is a risk factor for many cancer types including cancer of the oral cavity, pharynx, larynx, esophagus, liver, colorectum and breast. Risk of cancer increases with the amount of alcohol consumed. For several types of cancer, heavy drinking of alcohol combined with tobacco use substantially increases the risks of cancer. In 2010, alcohol-attributable cancers were estimated to be responsible for 337,400 deaths worldwide, predominantly among men.