Why some women are more prone to develop cervical cancer

Cervical cancer, or cancer of the uterine cervix, is caused by abnormal growth of cells, which can spread to other parts of the body. Researchers at the Indian Council of Medical Research (ICMR) and National Institute of Cancer Prevention and Research (NICPR) have found why some women are more prone to this cancer. This may help develop early diagnostic tests in the future.

Researchers found a correlation between the composition of three micro-RNA genes in the DNA and the risk for a person to develop cervical cancer. Micro-RNAs, which are small length genes, remain in the RNA form and do not get translated into proteins unlike most other genes. They bind to the RNA of a certain class of genes.

In this way, a micro-RNA regulates the expression of a number of genes and processes in an individual. It has emerged that the composition of the nucleotide at certain positions of micro-RNA genes — miR146, miR196a2 and miR499 — decides the risk for a woman getting cervical cancer.

Scientists decided to study these micro RNA genes as previous studies have shown that variations in nucleotide composition at particular positions affect susceptibility in several forms of cancer. They wanted to find whether it was the case for cervical cancer as well. Read More

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